For those out of the loop it been made common knowledge that Sam Raimi has been signed up for directing Spider-Man 4 and thus Tobey Maguire has also said he will join in as well.
Raimi signing up for the directors seat is believed to have been a requirment from Tobey, and Raimi would only sign on if he got "free reins" like in the two first movies, after being supposedly forced upon him to do Venom in the third movie (a character he apparently doesn't like).

So with the sudden media talk of a forth movie to enter production, who would you like to see as the Villain(s)? We've already seen the Green Goblin, Doctor Octopus, Green Goblin 2, Sandman, and Venom. Who's next?

Personally i think it might be about time for Connors to turn into Lizard as a "side villain" when it comes to the main antagonist im not so sure tho. Kingpin might be interesting but would Michael Clarke Duncan play him again? Like in Daredevil? Or did that movie suck so bad they should really just disregard it totally and find a new actor to play him so we don't have to be reminded of that utter crap.

Anyone else? Mysterio maybe?

Lets put in a Spiderman Sci-Fi twist & bring Deathlok into the Mix